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For instance, Curcumin has been shown to covalently bind to the Cys151 residue of KEAP1, thereby stabilizing NRF2 and enhancing antioxidant effects

Rodd 2018)

Journal of Agricultural and Food Chemistry, 73 (11), 63856399

The acquired resistance aligned with decreases in cell proliferation and in the extent of lipid peroxidation, as well as with an increase in the expression of GPX4 upon differentiation