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NMIBC recurs at a rate of 5080% and has a 14% chance of progression to muscle-invasive cancer after transurethral resection (TUR) alone [4]

AKG is also a precursor of glutamine and glutamate, which stimulate protein synthesis

10.3390/biom9090435 55

This suggests that bacterial release is necessary for a hGSHS -to- GSHS switch in gene expression in nodule tissue, which is a requirement for nodule development