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However, these models have not successfully recapitulated CD until recently, when Abadie and colleagues modified the DQ8-D d -IL-15tg model to overexpress IL-15 in intestinal epithelial cells under the villin promoter, resulting in the DQ8-D d -villin-IL-15tg model (Abadie et al, 2022

References: [1] 9087984_Effect_of _Epitalon_on_biomarkers_of _aging_life_span_and_ spontaneous_tumor_incidence _in_female_Swiss-derived _SHR_mice [2] gov/11550036/ [3] pmc/articles/PMC8365293/ Epithalon Specifications: Sequence: H-Ala-Glu-Asp-Gly-OH Molecular Formula: C14H22N4O9 Molecular Weight: 390.349 Thymalin Specifications: Sequence: Pyr-L-Ala-L-Lys-L-Ser-L-Gln-Gly-Gly-L-Ser-L-Asn-OH Molecular Formula: C33H54N12O15 Storage: Lyophilised peptide must be stored at -20C and peptide solution at 4C Epithalon Thymalin Peptide Stack is for Research use only

ACS Nano 2015, 9, 251259