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It plays integral roles in: Immune regulation Cancer suppression (anti-proliferative and pro-apoptotic signaling) Mitochondrial function and redox balance Hormonal feedback loops, including cortisol and estrogen/testosterone rhythms Aging diminishes melatonin output by up to 75%, leading to weaker circadian cues and downstream systemic dysfunction

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The key step in the induction of mutagenic effects by Cr(VI) has been found to be the formation of Cr(III)-containing complexes between DNA and proteins [74,75]

Exosomes in tumor microenvironment: novel transporters and biomarkers