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Because the Kras G12D -Myc axis has been suggested to induce Nrf2 gene expression and increased the activity of Nrf2 in pancreatic cancers ( Another unique regulator of the pentose phosphate pathway is the tumor suppressor p53, which inhibits the pentose phosphate pathway through binding to G6PD and preventing the formation of the active dimer (Jiang et al., 2011)

Conversely, the anti-inflammatory M2 macrophages favor mitochondrial oxidative phosphorylation

Muto Y, Sato S, Watanabe A, Moriwaki H, Suzuki K, Kato A, et al

(2003) Detoxification of electrophilic compounds by glutathione S-transferase catalysis: determinanats of individual response to chemical carcinogens and chemotherapeutic drugs