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This recent preclinical study showed that the metabolism of racemic ketamine to (2 R ,6 R )-HNK is necessary for the antidepressant effects of ketamine, and that this metabolite itself shows antidepressant-like effects in mice that seem to be independent of the NMDAR

In reality, everyday stress, poor sleep, inflammation, and aging affect almost everyone

Some may experience minor side effects such as: Redness or swelling at the injection site Temporary soreness or bruising Less commonly, side effects could include: Mild headaches Nausea Itchy skin or rash Should you notice any prolonged side effects, we recommend speaking with your GP or calling NHS 111 for advice

doi: 10.1038/s41422-019-0263-3 39 YadavPSharmaPSundaramSVenkatramanGBeraAKKarunagaranD