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Third, PDK4 inhibits the TCA cycle and reduces the production of PUFAs to enhance ferroptosis resistance [18] [Figure 4A]

Senescent cells can secrete soluble inflammatory cytokines, growth factors, interleukins, chemokines, degradative enzymes such as matrix metalloproteinase, and insoluble extracellular matrix components

The first and second columns in Table 6 show the changes in blood levels of various metabolites in autistic children compared to normal patients in two different clinical studies [14, 15]