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Figure 1 shows a simple model of GSNO metabolism and its interactions with other molecules in cells where different reactions including S -nitrosylation, S -transnitrosation, and S -glutathionylation are involved (Hogg, S -nitrosylation as this kind of post-translational modification can alter the function of the affected proteins (Astier et al., Figure 1 1 -SH) through a process of S -transnitrosation between proteins

Nitric oxide (NO) has long been indicated to play various physiological roles, with emphasis on the immune and cardiovascular systems (Lundberg et al., 2008)

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Patients who experience COPD exacerbations have a significantly higher mortality rate than those with stable COPD