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At the follicle level, GHK-Cu appears to work through several parallel mechanisms that have nothing to do with blocking androgens: What GHK-Cu does not do, based on the mechanistic literature, is directly block the 5-alpha reductase enzyme the way finasteride does

Genes Dev 38:151167

On the other hand, opioids increase the levels of ROS and decrease the activity of superoxide dismutase, catalase, and glutathione peroxidase that function as enzymatic antioxidants

Protective effect of norepinephrine, dopamine and N-methyldopamine against chemically-induced oxidative ferroptosis in HT22 neuronal cells: Protein disulfide isomerase as a mechanistic target for protection