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The diagnosis of dementia was made according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.17 Only persons with a duration of symptoms longer than 6 months and a score for severity of dementia of 1 or higher on the Clinical Dementia Rating Scale were considered incident cases.18 Patients with suspected cognitive deficits for whom definite dementia could not be established underwent annual reassessment

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If a research program has a genuine reason to work with GLP-1 compounds, the same supplier-vetting standard applies CoA, endotoxin testing, batch traceability and animal work should go through the appropriate institutional review process (IACUC)