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Firstly, 3696 parallel linear models were constructed, re-setting the reference factor to compare all possible permutations of diagnostic class, with peptide quantification as outcome variables and categorical demographic information as explanatory variables: Secondly, 3696 parallel linear models were constructed with peptide quantification as outcome variables, and continuous demographic information as explanatory variables: This similar second model was constructed to allow consideration of nuanced interparticipant differences that may be lost by stratifying individuals into discrete classes

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All of these showed efficacy in animal models

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