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ThorpELiGSeimonTAKuriakoseGRonDTabasI.Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-/- and Ldlr-/- mice lacking CHOP

The activation of LXRs, triggered by the accumulation of cholesterol in cells, results in enhanced cholesterol efflux and diminished cholesterol import (Luo et al., 2020)

Although no highly potent small-molecule ligands have yet been reported for ATF proteins, researchers are creatively adapting the PROTAC concept for transcription factor degradation