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2 The logic is elegant: after a carbohydrate-rich meal, most of the glycemic excursion is governed not by how fast the pancreas secretes insulin but by how fast glucose arrives in the small intestine to be absorbed

Modern interest in NAD biology was reinvigorated by the 2000 discovery by Imai, Armstrong, Kaeberlein, and Guarente that the silent information regulator 2 (Sir2) family sirtuins are NAD-dependent protein deacylases, establishing a direct link between cellular NAD availability and gene-silencing, metabolic, and aging-related signaling pathways

[DOI] [PMC free article] [PubMed] [Google Scholar] Liao Y, Kristiansen A-M, Oksvold CP, Tuvnes FA, Gu N, Rundn-Pran E, Ruth P, Sausbier M, Storm JF

doi: 10.1093/sleep/11.5.425 19 VerrilloEBizzarriCBruniOFerriRPavoneMCappaMet al