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However, NOX enzymes contain heme-binding histidine residues within the third and fifth transmembrane domains that can accept electrons before transferring them to oxygen on the opposite, exofacial or lumenal side of the membrane

Intraperitoneal injection of 4-hydroxynonenal (4-HNE), a lipid peroxidation product, exacerbates colonic inflammation through activation of Toll-like receptor 4 signaling

Methods 13 , 731740 (2016)

This review elucidates the impact of lipid imbalance on depression highlighting how dyslipidemia not only makes individuals prone to depression but also exacerbates the progression of depression (including the occurrence of some comorbidities of depression)