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Studies have shown that follicular fluid from women with endometriosis contains increased ROS and lipid peroxidation byproducts, which correlate with lower oocyte quality and fertilization rates ( Additionally, the persistent inflammatory environment alters the expression of genes involved in cumulus expansion, ovulation, and corpus luteum formation

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NRF2 acetylation represents a key post-translational modification, characterized by the addition of acetyl groups (CH3CO-) to specific lysine residues on the NRF2 protein within the cell