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Notably, MCP-1, also known as chemokine ligand 2 (CCL2), plays a pivotal role in promoting BBB instability by facilitating the recruitment of monocytes/Ms into CNS compartment and contributing to the reorganization of TJ and the actin cytoskeleton (Stamatovic et al., 2003)

However, several histological abnormalities were found in these mice, abnormalities that spanned several tissues and included chronic inflammation and hyperplasia of the gastric epithelium, calcification in the brain, testicular atrophy, loss of cytoplasmic granules in the striated duct cells of the salivary gland, and thinning of compact bone

Rarely, mild nausea, headache, or skin reactions may occur

IRS-CIRS measurements The data mentioned in the previous sections indicate that immune parameters may have significant potential as diagnostic biomarkers for IMDD