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Astrocyte epigenomics and heterogeneity Astrocytes are also heterogenous by brain region and physiological or pathological conditions, showing transcriptional, morphological, and physiological heterogeneity, as already described

Accumulated ROS cause oxidative damage to lipids, DNA, and proteins, creating a pro-degenerative cellular environment (Chang and Chen, 2020

The limiting dilution sphere formation assay showed that the cells that were treated 20 days earlier with the combination of sertraline and 6 Gy irradiation were intrinsically rewired and presented a decreased sphere formation efficiency, indicating a 3-fold reduction and loss of long-term self-renewal capacity ( p = 0.0061) (Fig

USA 73 , 25792583 (1976)