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Changes in liver histology outcomes were defined as PROGRESSION (from MASLD to MASH or at least a 1-point increase in the fibrosis score) and REGRESSION (from MASH to MASLD without fibrosis worsening or at least a 1-point decrease in the fibrosis score)

Of note, data on the role of circadian machinery in anti-tumor immunity suggest a possible role of circadian machinery in the development of cold tumors through the accumulation of immune-suppressive cells in the microenvironment and through the regulation of the expression of PDL1 and CTLA4, two major targets of the current immunotherapy 126

Psychiatry 113 TakahashiK.YanaiS.TakisawaS.KonoN.AraiH.NishidaY.et al (2019)

Examples of zwitterionic surfactants include cocamidopropyl betaine and sulfobetaine, both of which are valued for their gentle cleansing and foaming capabilities