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10.1007/s10616-021-00514-y 202 PangH.ZhouY.WangJ.WuH.LiuX.GaoF.et al (2021)

The NHS access journey, should CagriSema receive approval, would then follow a separate NICE appraisal process the same pathway that Wegovy and Mounjaro have navigated

The standard precaution applies: individuals with active malignancies should avoid exogenous growth-modulating peptides outside of clinical trials

The peptide stimulates expression of early growth response 1 (EGR-1) gene, which regulates cytokine and growth factor generation along with early extracellular matrix formation, while simultaneously inducing its repressor NAB2 to prevent excessive angiogenic signaling