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Constant, discriminative, and almost non-overlapping relative shifts in mean TW CCS N2, meas were obtained for demethylation ( 6.5 2.1 2 ), oxygenation (hydroxylation + 3.8 1.4 2 , N-oxidation + 3.4 3.3 2 ), acetylation (+ 13.5 1.9 2 ), sulfation (+ 17.9 4.4 2 ), glucuronidation (N-linked: + 41.7 7.5 2 , O-linked: + 38.1 8.9 2 ), and glutathione conjugation (+ 49.2 13.2 2 )

The longest trial conducted to date was terminated following an incident of fatal myocardial infarction, which was determined to be unrelated to administration of CJC-1295 itself [8]

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