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Meanwhile, a number of previous studies have shown that caspase-3-dependent apoptosis and caspase-1-dependent pyroptosis are also involved in tubular cell death in diabetic nephropathy 14,15

Acknowledgements We acknowledge the DSFP contract, King Saud University, Riyadh, KSA (to SYA) and the Slovak Grant Agencies VEGA Project 1/0482/20 and APVV Project 19-0087

(Heffernan et al., Endocrinology, 2001) Early human trials: promising but modest Six Phase I/II human clinical trials were conducted, enrolling roughly 900 participants total