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Natural Radiance Enhancers : Glutathione and Kojic Acid combine to whiten dark spots, hyperpigmentation, and unevenness with subtle revelation of a naturally radiant canvas

Abbreviations LDs: Lipid droplets ER: Endoplasmic reticulum TAGs: Triacylglycerols DAGs: Diacylglycerols SEs: Sterol esters BBB: BloodBrain Barrier DGAT: Diacylglycerol acyltransferase GPAT: Glycerol 3 phosphate acyltransferase AGPAT: Acylglycerol 3 phosphate PAP: Phosphatidate phosphate FATP: Fatty acid transport protein MGAT2: Monoacylglycerol acyltransferase SCD1: Stearoyl-CoA Desaturase 1 nLDs: Nuclear lipid droplets PLIN5: Perilipin 5 PLIN1: Perilipn 1 PLIN2: Perilipn 2 PLIN3: Perilipn 3 PKA: Protein kinase A PKB: Protein kinase B SIRT1: Sirtuin1 CRABP1: Cellular retinoic acid-binding protein 1 ATRA: All-transretinoic Acid TLR: Toll-like receptor EGF: Epidermal growth factor RIG-I: Retinoic acid-inducible gene-I PRR: Patter recognition receptor IFNs: Interferons NDRG1: N-myc downstream-regulated gene 1 USP15: Ubiquitin Specific Peptidase 15 PGC-1: Peroxisome proliferator-activated receptor gamma 1 AMPK: AMP-activated protein kinase LDMC: Lipid droplets mitochondrial coupling MFN2: Mitofusin2 CMA: Chaperon-mediated autophagy LDAF1: Lipid droplet assembly factor 1 MGAT2: Monoacylglycerol acetyltransferase 2 FATP: Fatty acid transporter protein SCD1: Stearoyl COA desaturase 1 IGTP: Interferon-gamma inducible guanine IFI47: Interferon-gamma inducible protein IIGP1: Interferon-inducible guanine triphosphatase 1 TGTP1: T cell-specific GTPase1 cPLA2: Phospholipase A2 SREBP: Sterol regulatory binding element protein SKI-1/S1P: Subtilisin kexin isozyme-1/site 1 protease PI3K: Phosphoinositide 3-kinase AUP1: Ancient ubiquitous protein 1 NS4A: Nonstructural protein 4A NS4B: Nonstructural protein 4B NS5A: Nonstructural protein 5A NS3: Nonstructural protein 3 DENV: Dengue virus JEV: Japanese encephalitis virus ADRP: Adipose differentiation-related protein PAR: Peroxisome proliferator-activated receptor gamma HSL: Hormone-sensitive lipase ATGL: Adipose triglyceride lipase ZIKAV: Zika virus HCV: Hepatitis C virus MAP1LC3: Microtube-associated protein 1 light chain 3 AD: Alzheimer's disease PD: Parkinson's disease ALS: Amyotrophic lateral sclerosis MCT: Monocarboxylate transporter JNK: C jun N terminal kinase Syn: Alpha-synuclein CNS: Central nervous system ROS: Reactive oxygen species MRP: Multidrug resistance-associated protein ABC: ATP binding cassette P-gp: P glycoprotein DMPC: Dimyristoyl-sn-glycerol-3-phosphocholine DMPG: 1,2-Dimyristoyl-sn-glycerol-3-phosphoglycerol DSPE: 1,2-Distearoyl-sn-glycerol-3-phosphoethanolamine PEG: Polyethylene glycol FIT: Fat storage-inducing transmembrane protein References Acevedo N, Waggoner J, Rodriguez M et al (2017) Zika virus, chikungunya virus, and dengue virus in cerebrospinal fluid from adults with neurological manifestations, Guayaquil, Ecuador

While treatments like chemical peels or laser toning can help reduce pigmentation, dark skin cannot be naturally transformed into a fair complexion

Iron overload has been observed in OA patients