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TNF- induces mitophagy in rheumatoid arthritis synovial fibroblasts, and mitophagy inhibition alleviates synovitis in collagen antibody-induced arthritis

These results highlight a robust set of A45-specific biomarker candidates, reflecting perturbations in amino acid and energy metabolism as well as potential links to oxidative stress and inflammation

Mechanism of Action: Methotrexate interferes with DNA synthesis, repair, and cellular replication by inhibiting the enzyme dihydrofolate reductase

Soy consumption is supposed to have protective effects against cardiovascular disease by cholesterol-lowering and blood pressure improvement action and in the prevention of cancer or diabetes and it also supports bone health and the management of menopause symptoms (Reference Ding, Pan and Manson2Reference Mosallanezhad, Mahmoodi and Ranjbar8)