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By simulating the networks dynamic evolution and optimizing the models logic rules using an evolutionary method, the study identified 3-phosphoinositide-dependent protein kinase 1 as a pivotal target for cellular senescence, capable of converting cells from a senescent state to a quiescent state (Zhang et al., 2024)

For instance, increase of Akkermansia, Catabacter, Lactobacillus, Bifidobacterium, Bifidobacteriaceae, Ruminococcaceae, Verrucomicrobiaceae , and reduction in Roseburia, Faecalibacterium, Prevotellaceae, Blautia, Coprococcus , and Lachnospira have been noted in individuals with PD (159, 169)

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease