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10.1038/s41418-018-0225-1 Cell Death Differ

However, there are several avenues of research that may help mitigate these side effects while successfully downregulating immunosuppressive pathways

The vascular phenotype of the conditional deletion was milder than that of the germ line deletion (Fig 2A and B), likely due to delayed onset of the loss of Gpr124 function after tamoxifen injection

Phase 3 monotherapy results A post-hoc analysis of the phase 3 data showed cagrilintide 2.4 mg monotherapy produced 11.8% average body weight reduction versus 2.3% for placebo over 68 weeks