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This is consistent with reports 30 that LNPs consisting of commercially available ionizable lipids, such as DLin-MC3-DMA, can activate the immune system, resulting in CARPA, an acute immunologic response that can lead to anaphylactic-like shock

Age-related vulnerabilitiessuch as reduced renal function, decreased bone mineral density, and a greater risk of sarcopenia and malnutritioncan exacerbate complications associated with a restrictive high-fat diet [209]

Oncogenic MSH6-CXCR4-TGFB1 feedback loop: a novel therapeutic target of photothermal therapy in glioblastoma multiforme

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