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[2] Examples of multienzyme complexes As noted above, especially in eukaryotes, multienzyme complexes, like multifunctional enzymes, are common in both anabolic and catabolic pathways, whereas few enzymes diffuse freely in solution

Given their substantial fat loss, elevated futile creatine cycling could contribute to thermogenesis during the observed weight loss 50

10.1016/j.amjmed.2014.04.015 30 DangolS.ChenY.HwangB

Compared to Ad cells, significantly increased 13 C 3 -lactate-derived metabolites in AR cells included pyruvate, acetyl-CoA, TCA cycle intermediates (fold change from high to low: oxaloacetate, succinate, -ketoglutarate, malate, fumarate, isocitrate, and citrate), and TCA cycle-derived metabolites (glutamate, aspartate, and ribose-5-phosphate), indicating enhanced lactate uptake and oxidation as well as increased TCA metabolism (Fig