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The 26S proteasome is composed of a 20S catalytic core and two 19S regulatory caps on both ends of the 20S core

For patients with IBD, autoimmune history, or persistent GI inflammation, running both simultaneously addresses the cause and the damage at the same time

At a genome-wide significant level, three loci (ABCG2, SLC2A9, and CUX2) have been identified in association with renal urate overload, whereas four loci (ABCG2, SLC2A9, CUX2, and GCKR) have been linked to renal urate underexcretion