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Therapies trying to build upon these insights, might focus on posttranscriptional regulators, including ncRNAs and RBPs, or their targets, such as PGC-1/ or MFN1/2

Western medications currently used clinically to treat osteoporosis include bone formation enhancers, bisphosphonates, denosumab, receptor activator inhibitors, selective oestrogen receptor modulators and hormone replacement therapies, as suggested by international guidelines including the 2022 Hormone Therapy Position Statement of The North American Menopause Society for the primary prevention of bone loss as well as the dual-action drug sclerostin monoclonal antibody [11, 12] Although these medications may increase bone density and reduce the risk of fractures in patients, they are still associated with common adverse effects [11, 12] including gastrointestinal symptoms, osteonecrosis of the jaw, atypical femoral fractures and increased cardiovascular risks with prolonged use

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