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The primary routes for permeation across the BBBinclude passive diffusion (lipid soluble solutes), ABC transporter efflux, carrier-mediated influx, and receptor-mediated transcytosis (Abbott et al., 2010)

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These authors showed that the synbiotic based on Lactobacillus salivarius was involved in the activation of pathways related to fat and carbohydrate metabolism, cell adhesion, and immune response, while the synbiotic based on Lactobacillus plantarum was involved in the upregulation of expression of genes involved in metabolic pathways (154)

Summary The importance of GSH in health and disease is a subject of active research, presentation, and publication