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We explained in the CY 2008 PFS final rule, when changing the plan of care recertification interval from 30 to 90 days, this was done to allow more flexibility to the physician/NPP to order the appropriate amount of therapy for each patient's needs (72 FR 66333)

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In addition, CPT was coupled to the Bn analog [d-Tyr 6 ,-Ala 11 ,d-Phe 13 ,Nle 14 ]Bn(614) by a carbamate linker exhibiting great cytotoxicity in Bn-receptor overexpressing cells while cells without these receptors were not affected (Moody et al., 2006)