Carnitine transmembrane transport Carnitine transport in and out of cells depends on specific transporters, among which OCTN2 transporter plays a key role
The protective role of selenium on the toxicity of cisplatin-contained chemotherapy regimen in cancer patients
A study examining choline intake in 664 subjects enrolled in the cross-sectional study Nonalcoholic Steatohepatitis (NASH) Clinical Research Network (NCT00063622 and NCT00063635) showed that postmenopausal women with self-reported choline intake less than 50% of the adequate intake, had faster progression of NASH as shown by increased liver fibrosis, while no associations were found in children, men, and premenopausal women ( PEMT ) ( In the same line with prenatal choline intake and its effect on cognition and memory, in adult individuals, sustained choline intake between 187.6-399.50 mg/day, is linked to reduced risk of cognitive decline, improved learning ability, verbal fluency, working memory, mental processing speed, and attention span, compared to individuals consuming less than 187.6 mg/kg of total choline ( 2 Choline and choline-containing metabolites contribute to immune cell activation and function Metabolic reprogramming and lipidomic remodeling are hallmarks of immune cell activation and are closely intertwined with functional responses ( de novo PC synthesis by pharmacological inhibition of ChoK or CTP:phosphocholine cytidylyltransferase alpha (CCT), alter the cellular phospholipid pool composition, the integrity of the mitochondrial membrane, and the overall cellular activity, leading to immune dysfunction and dysregulated inflammation across species ( 2.1 Myeloid cells Myeloid cells are frontline immune defenders that restore tissue homeostasis after infection or tissue damage
Mokashi P, Khanna A, Pandita N (2017) Flavonoids from Enicostema littorale blume enhances glucose uptake of cells in insulin resistant human liver cancer (HepG2) cell line via IRS-1/PI3K/Akt pathway
