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Nanoparticles can enhance the permeability of antioxidants at scene of the tumour and the less doses may be required to cure the disease so the toxicity level will be less [304]

Free Radic Biol Med 1989;6, 593-597

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Connexin43 (Cx43) is the most widely expressed connexin, and it is abundantly present on the apical protrusions of RMCs, which are involved in maintaining the vascular permeability of the retina and the structure of the BRB, as well as in regulating cell apoptosis ( 3.2.3 RMCs and growth factors Hyperglycemia promotes the secretion of growth factors, such as vascular endothelial growth factor (VEGF) (Schmalen et al., 2021), which are involved in the regulation of neovascularization and cause retinal fibrosis in DR