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Production of tumour necrosis factor by cells exposed to sulphonamide reactive metabolites

Concerning the risks of developing hepatobiliary cancers in FIC-related diseases, they are due to an overexpression of pro-inflammatory cytokines, resistance to apoptosis, and, ultimately, cell hyperproliferation [25]

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Subclinical hypothyroidism, commonly considered an early sign of thyroid failure, is defined by elevated TSH concentrations but fT 4 concentrations within the reference range