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Tandon, M., Vemula, S

Experimental studies have shown that methylation activity is lower in hypothyroidism, and higher in hyperthyroidism

De novo and acquired resistance to endocrine therapy is a major challenge in treating ER+ breast cancers

This interaction is mediated through the pathways of the nervous, immune, endocrine, and metabolic systems, playing a pivotal role in modulating states of anxiety, depression, and cognitive abilities, also impacts the initiation and advancement of neurodegenerative disorders, including Alzheimer's (107) and Parkinson's diseases (108), along with other pathological states (Figure 3)