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doi: 10.1177/0961203314530488 29 SontheimerCLiggittDElkonKB

GGC has a credible biochemical basis and clinical evidence of cellular bioavailability

Our previous work identified the inhibition of glutaminase as a metabolism-based strategy to combine with CDK4/6 targeting therapy [36], a combination subsequently corroborated as effective to overcome CDK4/6i resistance in esophageal squamous cell carcinoma [92] and lung cancer [93]