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The transdermal composition of claim 2 which provides at least one of the following release pattern in an In Vitro study employing dialysis membrane and a phosphate buffer of pH 7.4 i) at least 30 % release in 24 hrs and 70 % release in 72 hrs

Beyond stromal and hypoxic barriers, recent investigations (20232025) have highlighted the capacity of curcumin nano-systems to reverse the cold immune microenvironment of PDAC