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It circulates at relatively high concentrations when you're young, around 200 ng/mL in your 20s , and drops steadily with age, reaching roughly 80 ng/mL by your 60s

This endothelial protection aligns with the compounds nitric oxide pathway modulation and its ability to upregulate protective gene expression in vascular endothelial cells making it a potentially interesting subject for further cardiovascular research, particularly in the context of inflammation-driven vascular disease

Angiogenic and Endothelial Pathways (Sikiric et al., 2019) BPC-157 acts as a balanced angiogenic modulator, supporting vascular remodeling via VEGFR2AKTeNOS and ERK1/2 signaling