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In further embodiments, the invention encompasses a method of providing muscular therapy by contacting a cell expressing NNMT with a NNMT inhibitor (such as a cation of Formula I or IA, or otherwise disclosed herein) and one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulates intracellular NAD+ levels to provide muscular therapy

Each batch undergoes independent analytical testing to verify: Compound identity Assay accuracy Purity confirmation Microbial safety Endotoxin levels Heavy metal screening Full batch traceability Research Use Limitation Used solely for in vitro experiments Not permitted for clinical trials involving humans Not permitted for human or veterinary administration Not permitted for investigational human use Independently analysed by Liquilabs s.r.o

[DOI] [PMC free article] [PubMed] [Google Scholar] 220.Holen, K., Saltz, L

The connection to NAD+ biology adds another dimension of interest