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Trends in Molecular Medicine

The first sub-analysis involved stratifying patients based on their AHM initiation status: newly-initiated users (patients who started AHMs on or after January 1, 2011, with no prior recorded use) and prevalent users (patients with a history of AHM use before January 1, 2011)

First, exposure to AHMs was defined based on prescription data, which cannot confirm whether the medications were dispensed or taken

When this barrier is disrupted, RPE cell activation occurs, leading to the proliferation, epithelial-mesenchymal transition (EMT), and secretion of extracellular matrix molecules, thus promoting vitreoretinal disorders, including proliferative vitreoretinopathy (PVR), age-related macular degeneration (AMD), and proliferative diabetic retinopathy (PDR) [13]