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Froum, a diplomate of both the American Academy of Periodontology and the American Academy of Osseointegration, is a volunteer professor in the postgraduate periodontal program at SUNY Stony Brook School of Dental Medicine

Jun 2021;18:159-164

N,Nbis-(2-mercaptoethyl) isophthalamide (NBMI), a lipophilic thiol-based chelator with selective affinity for ferrous iron, has demonstrated superior brain chelation efficacy in a mouse model of brain iron overload, making it a promising candidate for IN formulations if its solubility limitations can be addressed (Cheng et al., 2022)

The cGAS/STING pathway thus serves as a critical amplifier of the vicious cycle, linking DNA damage-triggered inflammation to ferroptosis execution