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Statistical analysis was performed using an unpaired two-tailed Students t-test ( b - g , i ), one-way ANOVA, followed by Dunnetts test ( k , m , o , and q ), two-tailed Fishers exact test ( h , l , n , and p )

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Beyond traditional DNA methylation, SeNPs have been instrumental in expanding our understanding of Ses role in the epigenetic landscape, particularly through the modulation of histone methylation via HMT expression and SAH depletion