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1 Introduction Neuropathic pain is a debilitating neural disorder following the disruption of neurons function and structure, mainly in the somatosensory system ( Chronic constriction injury (CCI) is a model of neuropathic pain, based on nerve damage caused by actual or potential tissue stimuli ( Following nerve damage, the signals released from the nerve terminals contribute to microglial activation and propagation of inflammatory cytokines ( Astaxanthin (AST), 3,3-Dihydroxy-beta,beta-carotene-4,4-dione, is a natural and red-orange keto-carotenoid that belongs to xanthophylls ( Therefore, in this study, we sought to investigate the effects of AST on CCI-induced neuropathic pain and motor dysfunction, highlighting its anti-inflammatory and antioxidant capabilities passing through opioid/benzodiazepine receptors

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