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Evaluation and management of peripheral nerve injury

As a note, -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptors are important for the initial stages of remyelination after experimentally induced demyelination, where the binding of glutamate released from active axons within the lesion promotes proliferation, survival and differentiation of OPCs during development and adulthood in rodents (Gautier et al., 2015

Although causal relationships remain to be fully established, these mechanisms provide a preliminary basis for exploring HPA-axis modulation as a therapeutic approach (Fig