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The participation of reactive aldehydes in LDL-receptor interactions was documented by several immunohistochemical analyses of atherosclerotic lesions from human aorta, using antibodies against various aldehyde adducts, such as HNE-histidine (Uchida et al., 1995), N-MDA-lysine (Uchida et al., 1997), and N-acrolein-lysine (FDP-lysine) (Uchida et al., 1998a), in which intense positivities were associated with cells, primarily macrophages

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This copper-binding tripeptide naturally occurs in human plasma, though levels decline substantially with age

Whether the perturbed activation of the Wnt signaling pathway affects the state of oxidative stress also needs further investigation