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Human papillomavirus-16 E6 activates the pentose phosphate pathway to promote cervical cancer cell proliferation by inhibiting G6PD lactylation

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Through testing of 12 EN25 analogs that were commercially obtained through Enamine, we found that EN25-7 and EN25-8 showed the best inhibitory potency against GCL with IC50s of 8.9 and 6.8 M, respectively (Fig