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Results of phase III studies of daratumumab in combination with bortezomib-thalidomide-dexamethasone, bortezomib-melphalan-prednisone, or lenalidomide-dexamethasone and of isatuximab in combination with bortezomib-lenalidomide-dexamethasone have shown significant benefit from treatment with anti-CD38 combinations in transplant-eligible or -ineligible NDMM patients, compared with standard treatment [13, 14, 86]

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Sampath et al., 2014)