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Additional evidence for stress comes from proteomic studies of Bruchs membrane tissue from AMD donors, revealing the presence of oxidative products (Yuan et al., 2010), and the AREDS studies, which have shown an association between reduced prevalence of AMD and high dietary intake of antioxidants ( in vitro and in vivo studies examining AMD-vulnerable cells and tissues, which we will further review below (Figure 2)

doi:10.1007/s00702-019-02083-z Mansour A, Hariri E, Shelh S, Irani R, Mroueh M

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No single adverse reaction led to discontinuation in 1% or more of VYVANSE-treated patients