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These interactions increase susceptibility to inflammation, worsening the disease

The dimer is further stabilized through a hydrogen bond network created by main- and side chain hydrogen bonds of residues from the loop between 7 and 5 (Tyr139, Ser142, Thr143, Gly144, Arg145) as well as residues from 5 (Phe147, Glu149, R152)

Macrophage targeted triptolide micelles capable of cgas-sting pathway inhibition for rheumatoid arthritis treatment

The APX activity is dependent on chloroplast ascorbate pool and low concentrations of the ascorbate substrate can result in irreversible inactivation of APX enzyme activity (Nakano and Asada, 1987