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Collectively, lactate acts as a metabolic checkpoint that can simultaneously suppress effector T cell functions while fostering immunosuppressive Tregs and, paradoxically, supporting the foundation of long-term immunity via memory CD8 T cells, highlighting a sophisticated and context-dependent immunomodulatory profile

Introduction Autism is a complex neurodevelopmental disorder that affects 1 in 54 children in the United States, with four times as many males diagnosed than females ( The heterogeneity of ASD can be observed in the neurologic, metabolic, and immunologic systems, etc